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Anti-DENND3 (Ser554) Antibody

Anti-DENND3 (Ser554) Antibody

ArtNr	ABC-AN1358
Hersteller	Abcepta
Menge	100 ul
Kategorie	Cell Biology Cytoskeleton small GTPases Rab Subfamily
Specific against	other
Host	Rabbit
Isotype	IgG
Alias	DENN Domain Containing 3,DENN Domain-Containing Protein 3,DENN/MADD Domain Containing 3,KIAA0870 DENN/MADD domain containing 3,KIAA0870DENN domain-containing protein 3
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Manufacturer - Category	Primary Antibodies; Signal Transduction
Manufacturer - Targets	The DENN (differentially expressed in normal and neoplastic cells) domain (DENND) is a poorly characterized protein module conserved throughout evolution (Marat, A.L., et al., 2011). Proteins bearing a DENN domain have recently emerged as the largest family of Rab GEFs. Among these DENN domain proteins, DENND3 is a GEF for Rab12; promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (Xu and McPherson, 2015; Matsui et al., 2011). ULK-mediated phosphorylation of DENND3 at serines 554 and 572 upregulates its GEF activity toward the small GTPase Rab12 (Xu and McPherson, 2015).
Bio Background	The DENN (differentially expressed in normal and neoplastic cells) domain (DENND) is a poorly characterized protein module conserved throughout evolution (Marat, A.L., et al., 2011). Proteins bearing a DENN domain have recently emerged as the largest family of Rab GEFs. Among these DENN domain proteins, DENND3 is a GEF for Rab12; promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (Xu and McPherson, 2015; Matsui et al., 2011). ULK-mediated phosphorylation of DENND3 at serines 554 and 572 upregulates its GEF activity toward the small GTPase Rab12 (Xu and McPherson, 2015).
Clonality	Polyclonal
Gene Name	DENND3
Subtitle	Our Anti-DENND3 (Ser554) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is
Calculated Molecular Weight	135890
Formulation	Antigen Affinity Purified from Pooled Serum

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Menge: 100 ul

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Lieferung vsl. bis 06.11.2025

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