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Anti-p62 (Thr269, Ser272) Antibody

Anti-p62 (Thr269, Ser272) Antibody

ArtNr	ABC-AN1506
Hersteller	Abcepta
Menge	100 ul
Kategorie	Oncology Neuroscience Protein Aggregation, Clearance & Misfolding By Cell Type Carcinoma Cell Biology Cell Status Adenocarcinoma Autophagy By Organ Lung Cancer
Specific against	other
Host	Rabbit
Isotype	IgG
Alias	A170 antibody,DMRV antibody,EBI 3 associated protein of 60 kDa antibody,EBI 3 associated protein p60 antibody,EBI3 associated protein of 60 kDa antibody,EBI3 associated protein p60 antibody,EBI3-associated protein of 60 kDa antibody,EBIAP antibody,FTDALS3 antibody,MGC127197 antibody,ORCA antibody,OSF-6 antibody,Osi antibody,OSIL antibody,Oxidative stress induced like antibody,p60 antibody,p62 antibody,p62B antibody,Paget disease of bone 3 antibody,PDB 3 antibody,PDB3 antibody,Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody,Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody,PKC-zeta-interacting protein antibody,Protein kinase C-zeta-interacting protein antibody,Sequestosome 1 antibody,Sequestosome-1 antibody,SQSTM 1 antibody,SQSTM_HUMAN antibody,Sqstm1 antibody,STAP antibody,STONE14 antibody,Ubiquitin binding protein p62 antibody,Ubiquitin-binding protein p62 antibody,ZIP 3 antibody,ZIP antibody,ZIP3 antibody
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cardiovascular; Metabolism; Signal Transduction; SARS-Human interaction partners
Manufacturer - Targets	The protein scaffold and signaling regulator p62 (also known as sequestosome1 (SQSTM1)) is important in critical cellular functions, including bone homeostasis, obesity, and cancer, because of its interactions with various signaling intermediaries. p62 is overexpressed in many human cancers and is induced during cell transformation. cdk1 phosphorylates p62 in vitro and in vivo at Thr-269 and Ser-272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis (Moscat et al., 2011). The lack of cdk1-mediated phosphorylation of p62 leads to a faster exit from mitosis, translating into enhanced cell proliferation and tumorigenesis in response to Ras-induced transformation (Moscat et al., 2011).
Bio Background	The protein scaffold and signaling regulator p62 (also known as sequestosome1 (SQSTM1)) is important in critical cellular functions, including bone homeostasis, obesity, and cancer, because of its interactions with various signaling intermediaries. p62 is overexpressed in many human cancers and is induced during cell transformation. cdk1 phosphorylates p62 in vitro and in vivo at Thr-269 and Ser-272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis (Moscat et al., 2011). The lack of cdk1-mediated phosphorylation of p62 leads to a faster exit from mitosis, translating into enhanced cell proliferation and tumorigenesis in response to Ras-induced transformation (Moscat et al., 2011).
Clonality	Polyclonal
Gene Name	SQSTM1 {ECO:0000303\|PubMed:16286508, ECO:0000312\|HGNC:HGNC:11280}
Subtitle	Our Anti-p62 (Thr269, Ser272) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutio
Calculated Molecular Weight	47687
Formulation	Antigen Affinity Purified from Pooled Serum

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Menge: 100 ul

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