FGF Receptor 3

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human
Applikationen WB, IHC
Protein Familie Tyrosine Kinase
Menge 100ug
Host Rabbit
ArtNr A0404
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
88kDa
Immunogen
A synthetic peptide of human FGFR3
Gene ID
2261
Swiss Prot
P22607
Synonyms
ACH; CEK2; JTK4; CD333; HSFGFR3EX;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Recommended Dilutions
WB 1:500-1:1000 IHC 1:50-1:100
illustration
Western blot analysis of extracts of Jurkat celllines, using FGFR3antibody.
Menge: 100ug
Lieferbar: In stock
Listenpreis: 289,30 €
Preis: 289,30 €
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