CD130

Hersteller	Abclonal
Typ	Antibody Polyclonal
Specific against	Human
Applikationen	WB, IHC
Protein Familie	Jak/Stat Pathway
Menge	100ug
Host	Rabbit
ArtNr	A0469
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
*	DESCRIPTION
Calculated MW	104kDa
Immunogen	A synthetic peptide of human IL6ST
Gene ID	3572
Swiss Prot	P40189
Synonyms	CD130; GP130; CDW130; IL-6RB;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliaryneurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100
illustration	Western blot analysis of extracts of MDA-MB231celllines, using IL6ST antibody.

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