Dicer

Hersteller	Abclonal
Typ	Antibody Polyclonal
Specific against	Human
Applikationen	WB
Protein Familie	Translational Control
Menge	100ug
Host	Rabbit
ArtNr	A0620
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
*	DESCRIPTION
Calculated MW	219kDa
Immunogen	A synthetic peptide of human DICER1
Gene ID	23405
Swiss Prot	Q9UPY3
Synonyms	DCR1; Dicer; HERNA; KIAA0928
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	DICER1, also named as DICER, HERNA and KIAA0928, belongs to the helicase family and Dicer subfamily. It is required for formation of the RNA induced silencing complex (RISC). DICER1 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. DICER1 cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. The antibody is specific to DICER1.
Recommended Dilutions	WB 1:500-1:1000
illustration	Western blot analysis of extracts of K562 cellstissue, using DICER1antibody.

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