ATR

Hersteller	Abclonal
Typ	Antibody Polyclonal
Specific against	Human
Applikationen	WB, IHC
Protein Familie	Cell Cycle
Menge	100ug
Host	Rabbit
ArtNr	A0862
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
*	DESCRIPTION
Calculated MW	301kDa
Immunogen	A synthetic peptide of human ATR
Gene ID	545
Swiss Prot	Q13535
Synonyms	FRP1; MEC1; SCKL; FCTCS; SCKL1;
Isotype	IgG
Purity	Affinity purification
Storage Buffer	Store at 4? or -20?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background	The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomycespombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Recommended Dilutions	WB 1:500-1:1000 IHC 1:50-1:100
illustration	Western blot analysis of extracts of UM celllines, using ATR antibody.

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