c-Myc

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Menge 200ug
Host Rabbit
ArtNr A0661-200ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
Calculated MW
57kDa
Immunogen
Fusion protein of humanc-Myc
Synonyms
MYC, MRTL, bHLHe39 , c-Myc, Myc proto-oncogene protein , Proto-oncogene c-Myc , Transcription factor p64
Purity
Affinity purification
Storage Buffer
Store at -20C or -80C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins, Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3, 4).
Illustration
Western blot analysis of extracts of NB4 using c-Myc antibody.
Gene Symbol
MYC
GeneID (Human)
4609
GeneID
4609
Protein MW
439
SWISS
P01106
Route
Recombinant Protein
Menge: 200ug
Lieferbar: In stock
Listenpreis: 540,10 €
Preis: 540,10 €
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