OCT4

Hersteller Abclonal
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Applikationen WB, IF, IHC
Menge 200ug
Host Rabbit
ArtNr A1481-200ug
Eclass 6.1 32160702
Eclass 9.0 32160702
Lieferbar
*

DESCRIPTION

Calculated MW
39kDa
Immunogen
Fusion protein of human OCT4
Gene ID
5460
Swiss Prot
Q01860
Synonyms
POU5F1; MGC22487; OCT3; OCT4; OTF3; OTF4
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
Oct-4 (POU5F1) is a transcription factor highly expressed in undifferentiated embryonic stem cells and embryonic germ cells (1). A network of key factors that includes Oct-4, Nanog, and Sox2 is necessary for the maintenance of pluripotent potential, and downregulation of Oct-4 has been shown to trigger cell differentiation (2, 3). Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker (4). Oct-4 exists as two splice variants, Oct-4A and Oct-4B (5). Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency, while Oct-4B may exist in some somatic, non-pluripotent cells (6, 7).
Recommended Dilutions
WB 1:200-1:500 IHC 1:50-1:100 IF 1:50-1:100 IP 1:20-1:50
illustration
Western blot analysis of extracts of various cell lines, using OCT4 antibody.
Menge: 200ug
Lieferbar: In stock
Listenpreis: 444,40 €
Preis: 444,40 €
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