P-Cav1.2 antibody

Hersteller Abclonal
Kategorie
Typ Antibody
Specific against Human, Mouse, Rat
Applikationen WB, IHC
Menge 100ug
Host Rabbit
ArtNr AP0092
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
*

DESCRIPTION

Immunogen
A phospho specific peptide corresponding to residues surrounding serine1927of mouse Cav1.2
Gene ID
12288
Swiss Prot
Q01815
Synonyms
MBC; Cav1.2; Cchl1a1; MELC-CC;
Isotype
IgG
Purity
Affinity purification
Storage Buffer
Store at -20? or -80?. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Background
The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homooligomers that interact with cholesterol and other lipids (1). Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease (2). Caveolins interact with multiple signaling molecules, such as G? subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS (1, 2). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7 (3-5). Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway (6).
Recommended Dilutions
WB 1:500-1:2000 IHC 1:50-1:200
Menge: 100ug
Lieferbar: In stock
Listenpreis: 366,30 €
Preis: 366,30 €
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