GW311616 hydrochloride

GW311616 HCl (GW311616A) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM. The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values > 100 uM for trypsin, cathepsin G, and plasmin, > 3 mM for chymotrypsin and tissue plasminogen activator). GW311616A is more potent than thetrifluoromethylketone inhibitor ZD8321 (Ki=13 nM). GW311616A is orallybioavailable in rat, dog and hamster despite moderate to high plasmaclearance, which indicates that clearance is predominantly extrahepatic.

GW311616A

C19H31N3O4S.HCl

>98%