Anti-TRAIL

ArtNr	ARP-10-P1419
Hersteller	American Research Products
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Polyclonal
Specific against	other
Citations	1. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA (December 1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 (6): 673-82. 2. Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (May 1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271 (22): 12687-90. doi:10.1074/jbc.271.22.12687. PMID 8663110. 3. Song JJ, Lee YJ (May 2008). Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily. Cell. Signal. 20 (5): 892-906.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TNF-related apoptosis-inducing ligand
Lieferbar
Description	Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 10 ( TNFSF10) detection. Tested with WB, IHC-P in Mouse, Rat.
Background	TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis. TRAIL has also been designated CD253 (cluster of differentiation 253). It is a member of Tumor Necrosis Factor Ligand Superfamily. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL has got 281 amino acid proteins. TRAIL mRNA is expressed at significant levels in most normal tissues. TRAIL binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII) and the receptors DcR1 and DcR2, leading to activation of specific kinases and transcription of genes.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminal of human TRAIL, different from the related rat sequence by one amino acid.
Form	Lyophilized
Specificity	Mouse, Rat. No cross reactivity with other proteins.
Storage	2-8C. For long term -20C after reconstitution.
Synonyms	TNF-related apoptosis-inducing ligand
References	1. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA (December 1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 (6): 673-82. 2. Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A (May 1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271 (22): 12687-90. doi:10.1074/jbc.271.22.12687. PMID 8663110. 3. Song JJ, Lee YJ (May 2008). Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily. Cell. Signal. 20 (5): 892-906.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Purification	Immunogen affinity purified.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

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Menge: 100 ug

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