Thyroid Peroxidase (TPO), Human, Recombinant

Recombinant human Thyroid Peroxidase (rHuTPO) Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called microsomal antigen has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx.100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3. Recombinant Human TP produced in SF9 is a glycosylated, polypeptide chain containing 834 amino acids and having a molecular mass of 92, 872 dalton.

-20C (aliquot), avoid freezing and thawing cycles

1 mg/ml

Sf9 insect cells expression system