Immunoglobulin G (IgG)

IgG is the most abundant immunoglobulin is plasma, found at a concentration of 8 to 18 mg/ml. This immunoglobulin plays a very important role in the defense against infection for newborns because of its transfer through the placenta during pregnancy. It readily diffuses into extravascular body spaces where it plays a major role in neutralizing bacterial toxins and in enhancing the phagocytosis of microorganisms. IgG binds to bacteria and these complexes adhere to phagocytic cells which have surface receptors specific for IgG.

-20C (aliquot), avoid repeated freeze and thaw cycles

>, 95% SDS-PAGE. Single arc by IEP against antisera to whole human serum

150, 000 dalton