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Immunoglobulin M (IgM)

Immunoglobulin M (IgM)

ArtNr	ARP-13-3035-1
Hersteller	American Research Products
Menge	200 ug
Kategorie	Peptides & Proteins Native Proteins
Typ	Proteins Native
Specific against	other
Purity	Single arc by IEP against antisera to whole human serum>95% by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IgM
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Description	Found in normal plasma at a concentration of 0.54-2.2 mg/ml. It is the first immunoglobulin produced during the immune response, the first antibody in neonates, and is involved in pathogenesis of autoimmune diseases. A diminished level of IgM is associated with Wiskott-Aldrich syndrome, an immunodeficiency disease.
Background	Immunoglobulin M (IgM) is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 970 kDa (in its pentamer form). Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites.
Form	Purified, in 50 mM Tris, pH 8.0 containing 200 mM NaCl and 0.05% NaN3
Storage	-20C (aliquot)
Synonyms	IgM
Concentration	7.27 mg/ml
Purity	Single arc by IEP against antisera to whole human serum >, 95% by SDS-PAGE
Source	Human myeloma plasma. Blood sample from donors was tested and found negative for HBsAg, HIV-1&, 2 antibodies, HCV and Syphilis
Notes	Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens.
Molecular Weight	950000

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Menge: 200 ug

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