Thyroglobulin

ArtNr	ARP-13-3047
Hersteller	American Research Products
Menge	100 ug
Kategorie	Peptides & Proteins Native Proteins
Typ	Proteins Native
Specific against	other
Purity	>98% by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TG, TGN, AITD3
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Description	Ultra Pure Human Thyroglobulin. Cellulose acetate electrophoresis shows one band only, indicating1 electrophoretic mobility. Polyacrylamide gradient gel electrophoresis shows a band, corresponding to a molecular weight of approx. 660 kDa. Under certain conditions the subunit band of thyroglobulin may also be observed at 330 kDa Immunological identity verified by Thyroglobulin RID Presence of IgG not discernable by Thyroglobulin RID Protein determination by the method of Lowry and OD (280nm, 1cm, 0.1%): 1.04, which corresponds to 9.21mg/ml (dispensing volume).
Background	Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
Form	Purified protein, in 0.02M NH4HCO3, may contain traces of buffer salts
Storage	-20C (aliquot)
Synonyms	TG, TGN, AITD3
Purity	>, 98% by SDS-PAGE
Source	Human Thyroid. Blood sample from donors was tested and found negative for HBsAg, HIV-1&, 2 antibodies, HCV and Syphilis
Notes	Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens.
Molecular Weight	660000

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Menge: 100 ug

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