SensoLyte® Fluorescent ß-Amyloid (1-42) Sampler Kit - 1 kit

beta-amyloid, beta-amyloid (1-42)

Store component A at -20°C and protect from light and moisture. Component B can be stored at 4°C.

Fluorophore labeled beta-amyloid peptides have been used in investigating beta-amyloid's aggregation, generation and clearance, microglial activation and phagocytosis. The SensoLyte® Fluorescent beta-Amyloid (1-42) Sampler Kit provides three fluorescent beta-amyloid (1-42) peptides, two unlabeled control peptides and biotin labeled beta-amyloid (1-42) peptide. The sampler kit provides ample choices for researchers interested in beta-amyloid related experiments - Alzheimer's Disease (AD) is the most common neurodegenerative disorder in elderly people. It has been demonstrated that AD has biological causes and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Beta-Amyloid (1-40) (A?40) and beta-Amyloid (1-42) (A?42) are the main components of the above plaques; however, other forms of beta-Amyloid peptides are also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by ?-secretase and ?-secretase enzymes. Many studies suggest that A?42 or/and A?43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration, while A?40 is less neurotoxic.

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Fluorescent

Research use

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