C-Peptide-2, rat

Catalog Peptides / Catalog Peptides Gr / Peptides

RT

3161.7

This rat C-peptide-2 differs from the active human C-peptide by several amino acids, however conserved Glu at positions 3, 11, and 27 is essential for peptide activity. In rat medullary thick ascending limb, C-peptide stimulates Na+, K+-ATPase activity within a physiological concentration range. This effect is due to an increase in Na+, K+-ATPase turnover rate that is most likely mediated by protein kinase C-f phosphorylation of the Na+, K+-ATPase f-subunit. - Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic ?-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

No

12352202