AggreSure ß-Amyloid (1-40), human

Assays Kits Group 5 / Assays Kits Group 5 / Peptides

4 °C

4330.2

AggreSure beta-Amyloid (1-40) peptide is pretreated and tested for aggregation using SensoLyte® ThT A?40 Aggregation kit (Cat# AS-72213). Aggregation is guaranteed. The quantity is 0.25mg net peptide.
- Alzheimer's Disease (AD) is the most common neurodegenerative disorder in elderly people. It has been demonstrated that AD has biological causes and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Beta-Amyloid (1-40) (A?40) and beta-Amyloid (1-42) (A?42) are the main components of the above plaques; however, other forms of beta-Amyloid peptides are also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by ?-secretase and ?-secretase enzymes. Many studies suggest that A?42 or/and A?43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration, while A?40 is less neurotoxic.

Fluorescent

Reconstitute peptide in either 50mM Tris/150mM NaCl (pH 7.2) or 20mMHEPES/150mM NaCl (pH 7.2) at 0.25 mg/ml. Use water bath sonicatorto completely dissolve peptide if necessary. Do not vortex!

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