EndoClear™ human recombinant α-Synuclein protein - 1 mg

Catalog recombinant

Proteins

E.coli

Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for long-term storage. Avoid repeated freeze-thaw cycles

Full-length Recombinant human alpha-synuclein (GenBank Accession # NP_000336) was expressed in E. coli., and purified from bacterial lysate using proprietary method. Endotoxin was further removed by proprietary technique. Molecular weight of the recombinant alpha-synuclein protein is 14.5 kDa. alpha-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. alpha-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express alpha-Synuclein at very low levels. The physiological role of alpha-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

Neuroscience / Lyophilized

none (lyophilized)

The purified a-synuclein is supplied as lyophilized powder nearly salt free.

Research use