EndoClear™ mouse recombinant a-Synuclein protein

Catalog recombinant

Catalog Recombinant Proteins / Catalog Recombinant / Proteins

4 °C

14.41 kDa

Alpha-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. ?-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express ?-Synuclein at very low levels. The physiological role of ?-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade.

alpha-synuclein protein available in the market. - The sequence (Accession # NP_001035916) corresponding to the full-length mouse a-synuclein protein plus an affinity tag was expressed in E. coli. The recombinant a-synuclein protein was purified from bacterial lysate using proprietary method, including tag cleavage. The resulting protein contains an additional Gly at the N-term of the a-synuclein sequence. The calculated molecular mass of the recombinant a-synuclein protein is ~14.4 kDa.

none (lyophilized)

The purified a-synuclein is supplied as lyophilized powder nearly salt free.

No

12352202