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Anti-Nav1.6 Na+ Channel Antibody

Anti-Nav1.6 Na+ Channel Antibody

ArtNr	75-026-020
Hersteller	Antibodies Incorporated
Menge	20 uL
Kategorie	Antibodies Primary Antibodies
Format	Liquid
Applikationen	IP, IHC, ICC
Clon	K87A/10
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Konjugat/Tag	Unconjugated
Alias	Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibody
Manufacturer - Targets	Nav1.6 Na+ channel
Country of Origin	United States
Shipping Temperature	Shipped on ice packs
Storage Conditions	Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Molecular Weight	<200 kDa
Manufacturer - Research Area	Ion Channels and Modulators, Na+ Channels
Expiration	24 months from date of receipt
Immunogen	Synthetic peptide 459-476 (intracellular interdomain loop I-II) of rat Nav1.6 (accession number O88420)
Immunogen Species	Rat
Description	Our Anti-Nav1.6 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K87A/10. It is KO validated, detects human, mouse, and rat Nav1.6 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Target Description	Nav1.6 Na+ channel (sodium channel, voltage-gated, type 8, alpha subunit/ SCN8A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn8a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.6 Na+ channel is located at the nodes of Ranvier. It heavily participates in the regulation of nerve conduction velocity. It has been shown that Nav1.6 Na+ channel loss in roddents induces paralysis due to the failure of the neuromuscular junction (Wagnon et al., 2016).
Clonality	Monoclonal
Manufacturer - Specificity	No cross-reactivity reported
Concentration	1 mg/mL
Form	Purified by Protein A chromatography
Buffer	10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
Production Notes	Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Quality Control	Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
Quality Control: Application	ICC
Dilution Range: WB	1:250
Dilution Range: IHC	1:250
Dilution Range: ICC	1:250
Usage Statement	These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Manufacturer - Statement	We produce our Nav1.6 Na+ channel mouse monoclonal primary antibody from hybridoma clone K87A/10. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 20 uL

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Lieferung vsl. bis 28.08.2025

Express-Lieferung: 7 Tage sparen

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