MSH2 (DNA Mismatch Repair Marker)(MSH2/2622), CF740 conjugate, 0.1mg/mL

Flow, intracellular (verified), IF (verified), IHC, FFPE (verified), WB (verified)

MSH2

Mus musculus (mouse), Bos taurus (bovine)

Store at 2 to 8°C|Protect fluorescent conjugates from light

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Mus musculus (mouse), Bos taurus (bovine)

2 years

41116161

0.05% sodium azide (CAS 26628-22-8)

PBS, 0.1% rBSA, 0.05% azide

Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)

For research use only (RUO)

597656

Nucleus

Flow (intracellular) (verified)|IF (verified)|IHC (FFPE) (verified)|WB (verified)

#2622