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Anti-Thrombospondin 2/THBS2 Antibody Picoband®

Anti-Thrombospondin 2/THBS2 Antibody Picoband®

ArtNr	BOS-PA1417
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Bone Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". Am J Hum Genet 82 (5): 1122–9. 2. Hirose, Y., Chiba, K., Karasugi, T., Nakajima, M., Kawaguchi, Y., Mikami, Y., Furuichi, T., Mio, F., Miyake, A., Miyamoto, T., Ozaki, K., Takahashi, A., Mizuta, H., Kubo, T., Kimura, T., Tanaka, T., Toyama, Y., Ikegawa, S.A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.Am. J. Hum. Genet.82: 1122-1129, 2008. 3. Entrez Gene: THBS2 thrombospondin 2".
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Thrombospondin-2;THBS2;TSP2;
Lieferbar
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	160 kDa
Calculated Molecular weight	129991 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human
Manufacturer - Gene Name	THBS2
Gene Full Name	Thrombospondin-2
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Thrombospondin-2 (THBS2) is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. The THBS2 is mapped to 6q27 and it is located on chromosome 17. The gene was transcribed in fibroblasts, smooth muscle cells, and an osteosarcoma cell line. It functions as a protein inhibitor of tumor growth and angiogenesis and modulates the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human Thrombospondin 2, different from the mouse sequence by two amino acids.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Angiogenesis, Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Invasion/Microenvironment, Neural Signal Transduction, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription
Protein Name	Thrombospondin-2
Protein Function	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Subcellular Localization	Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
Description	Boster Bio Anti-Thrombospondin 2/THBS2 Antibody catalog # PA1417. Tested in WB applications. This antibody reacts with Human.
Tissue Specificity	High expression in invertebral disk tissue.
Sequence Similarities	Belongs to the thrombospondin family.

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BOS-PA1417-datasheet.pdf

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