Anti-GABA-A-R-Alpha4 Antibody

GABA-A-R-Alpha4

Shipped on ice packs

60 kDa

24 months from date of receipt

Rat

Gamma-aminobutyric acid receptor subunit alpha-4 or GABA AR alpha4 is encoded by the gene GABRA4. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 4 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha 4 has been found to be expressed in skeletal muscle tissue, adult mammalian kidney, heart and primarily in brain at the cell junction, synapse, and the postsynaptic cell membrane. Disorders involving the GABRA4 gene include autism, Status Epilepticus and restless legs syndrome.

Does not cross-react with other GABA-A receptor Alpha subunits

Purified by Protein A chromatography

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

WB Brain

1:250

We produce our GABA-A-R-Alpha4 mouse monoclonal primary antibody from hybridoma clone N398A/34. It is great in IHC, ICC, WB and is purified by Protein A chromatography.