Anti-Kv1.3 K+ Channel Antibody

Primary Antibody

United States

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Ion Channels and Modulators, K+ Channels

Synthetic peptide amino acids 485-506 (GGMNHSAFPQTPFKTGNSTATC, cytoplasmic C-terminus) of rat Kv1.3 (accession number P15384)

Kv1.3 K+ channel (also known KCNA3) is a member of the potassium channel, voltage-gated, shaker-related subfamily. This protein, encoded by the KCNA3 gene in human, is an efficient channel blocker. Kv1.3 K+ channel includes a shaker-type repeat in the fourth segment of a six membrane-spanning domains. Kv1.3 K+ channel plays a role in the repolarization of nerve cells after an action potential. It is also widely expressed on T and B lymphocytes'membranes (including inner mitochondrial membrane) and has an important function in T-cell activation, especially in the regulation of chronically activated effector memory T-cell immune responses (Chiang et al., 2017). It has been demonstrated that effector memory T-cells highly expressing Kv1.3 K+ channel are predominantely present in patient with Musltiple Sclerosis lesion and children with type-1 diabetes mellitus (Beeton et al., 2006).

No cross-reactivity reported

Purified by Protein A chromatography

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

1:500

1:100

We produce our Kv1.3 K+ channel mouse monoclonal primary antibody from hybridoma clone L23/27. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.