Anti-Kvbeta1.1 K+ Channel Antibody

Primary Antibody

United States

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Ion Channels and Modulators, K+ Channels

Synthetic peptide amino acids 7-28 (unique N-terminus) of rat Kv1.1 (TEHNLKSRNGEDRLLSKQSST; accession number NP_058999)

Voltage-gated potassium channel subunit beta-1 or Kvβ1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvβ1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3

Does not cross-react with Kvβ 1.2, Kvβ 1.3, Kvβ 2

Purified by Protein A chromatography

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC

1:10

We produce our Kvbeta1.1 K+ channel mouse monoclonal primary antibody from hybridoma clone K9/40. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.