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Anti-LRP6 Phospho-specific Antibody

Anti-LRP6 Phospho-specific Antibody

ArtNr	OAAI00462-100UG
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Targets for Rodent Neurosciences Antibodies By Cell Type Obesity Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, FC, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Zahid Khan et al. (2007), Molecular and Cellular Biology, 27(20), 7291-7301.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ADCAD2;low-density lipoprotein receptor-related protein 6;LRP-6;STHAG7.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Phospho Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Shipping Temperature	Wet Ice
Molecular Weight	180
Manufacturer - Application Additional Information	WB: 0.1-1 ug/ml \| ELISA: 0.01-0.1 ug/ml \| IP: 2-5 ug/ml \| IHC: 2-10 ug/ml \| FC: Not tested
Gene symbol	LRP6
Gene Fullname	LDL receptor related protein 6
Product format	Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
Reconstitution and storage	The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Description of target	Low-desnsity lipoprotein receptor (LDLR)-related protein 6 (LRP6) is a member of the LDLR family which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LRP5 cuases several Human diseases including bone mineral density variability1, endosteal hyperostosis, autosomal dominant osteopetrosis type I etc. The V171 mutation in LRP5 causes high bone density by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling. The activity of LRP5 and LRP6 can be inhibited by binding of some members of Dickkopf (DKK) family proteins. Upon stimulation with Wnt, LRP5 and LRP6 are phosphorylated at multiple sites including Thr 1479, Ser 1490 and Thr 1492 by kinases such as GSK-3 and CK1.
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	A synthetic peptide corresponding to the epitope KGTYF at a phosphorylation threonine1479 in LRP6 protein
Manufacturer - Specificity	LRP6
Concentration	100ug/200ul

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OAAI00462-100UG-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 29.01.2026

Express-Lieferung: 10 Tage sparen

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