SLAMF7 Antibody

ArtNr	OACA06765-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Obesity Cell Status Adenocarcinoma Mesothelioma Immunohistochemistry Western Blot ELISA Autophagy Cardiovascular Research Enzymes Other Fatty Acid Enzymes Proliferation Myocardial Infarction Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors." Tovar V., Del Valle J., Zapater N., Martin M., Romero X., Pizcueta P., Bosch J., Terhorst C., Engel P. Immunogenetics 54:394-402(2002). [2]Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs."Lee J.K., Boles K.S., Mathew P.A.Eur. J. Immunol. 34:2791-2799(2004). [3]Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J.Protein Sci. 13:2819-2824(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	19A;19A24 protein;CD2 subset 1;CD2-like receptor activating cytotoxic cells;CD2-like receptor-activating cytotoxic cells;CD319;CRACC;CS1;membrane protein FOAP-12;Novel Ly9;novel LY9 (lymphocyte antigen 9) like protein;protein 19A;SLAM family member 7.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Application Additional Information	WB: 1:500~2000IHC: 1:20~200
Gene symbol	SLAMF7
Gene Fullname	SLAM family member 7
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Nucleotide accession_num	NM_001282588
Protein accession_num	NP_001269517
Protein name	SLAM family member 7
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human SLAM family member 7 protein (23-226AA)
Concentration	Varies by lot. See vial for exact concentration.

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Menge: 100 ul

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Lieferung vsl. bis 25.12.2025

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