RAB5A Antibody

ArtNr	OACA06774-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Cytoskeleton Immunohistochemistry Western Blot ELISA Autophagy Cardiovascular Research Myocardial Infarction Primary Antibodies Immunostaining small GTPases Ras Subfamily Rab Subfamily
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	1.Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of early endosomal autoantigen 1 (EEA1)."Mishra A., Eathiraj S., Corvera S., Lambright D.G.Proc. Natl. Acad. Sci. U.S.A. 107:10866-10871(2010). [2]Structural basis of Rab5-Rabaptin5 interaction in endocytosis."Zhu G., Zhai P., Liu J., Terzyan S., Li G., Zhang X.C.Nat. Struct. Mol. Biol. 11:975-983(2004). [3]Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution."Terzyan S., Zhu G., Li G., Zhang X.C.Acta Crystallogr. D 60:54-60(2004).
Alias	RAB5;RAS-associated protein RAB5A;ras-related protein Rab-5A.
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	RAB5A
Gene Fullname	RAB5A, member RAS oncogene family
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Nucleotide accession_num	NM_001292048
Protein accession_num	NP_001278977
Protein name	Ras-related protein Rab-5A
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Ras-related protein Rab-5A protein (1-215AA)

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Menge: 100 ul

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