TEAD1 Antibody

ArtNr	OACA06775-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Melanoma Cell Biology Cell Status Adenocarcinoma Cell Metabolism Immunohistochemistry Western Blot ELISA Immunofluorescence Oxidative Stress Primary Antibodies CHiP By Organ Lung Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoidperipapillary chorioretinal degeneration)."Fossdal R., Jonasson F., Kristjansdottir G.T., Kong A., Stefansson H., Gosh S., Gulcher J.R., Stefansson K.Hum. Mol. Genet. 13:975-981(2004). [2]Structural insights into the YAP and TEAD complex." Li Z., Zhao B., Wang P., Chen F., Dong Z., Yang H., Guan K.L., Xu Y.Genes Dev. 24:235-240(2010). [3]Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain." Anbanandam A., Albarado D.C., Nguyen C.T., Halder G., Gao X., Veeraraghavan S.Proc. Natl. Acad. Sci. U.S.A. 103:17225-17230(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AA;NTEF-1;protein GT-IIC;REF1;TCF13;TCF-13;TEA domain family member 1;TEA domain family member 1 (SV40 transcriptional enhancer factor);TEAD-1;TEF-1;transcription factor 13;transcriptional enhancer factor 1;transcriptional enhancer factor TEF-1.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	TEAD1
Gene Fullname	TEA domain transcription factor 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Nucleotide accession_num	NM_021961
Protein accession_num	NP_068780
Protein name	Transcriptional enhancer factor TEF-1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Transcriptional enhancer factor TEF-1 protein (135-215AA)

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