EED Antibody

ArtNr	OACA06845-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Transcription Factors Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Myelofibrosis Mesothelioma Immunohistochemistry Western Blot ELISA Senescence Primary Antibodies By Organ Lung Cancer Heart & Blood Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)."Xu C., Bian C., Yang W., Galka M., Ouyang H., Chen C., Qiu W., Liu H., Jones A.E., MacKenzie F., Pan P., Li S.S., Wang H., Min J.Proc. Natl. Acad. Sci. U.S.A. 107:19266-19271(2010). [2]System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.Sci. Signal. 4:RS3-RS3(2011). [3]Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27." Zhang Y., Yang X., Gui B., Xie G., Zhang D., Shang Y., Liang J.J. Biol. Chem. 286:42414-42425(2011).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	COGIS;embryonic ectoderm development protein;HEED;polycomb protein EED;WAIT1;WD protein associating with integrin cytoplasmic tails 1.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	EED
Gene Fullname	embryonic ectoderm development
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Nucleotide accession_num	NM_001308007
Protein accession_num	NP_001294936
Protein name	Polycomb protein EED
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Polycomb protein EED protein (1-300AA)

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Menge: 100 ul

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