SUMO4 Antibody

ArtNr	OACA07320-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Cholesterol & Lipid Metabolism Neural Transcription Factors Molecular Targets for Neuroscience Neural Signaling Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes."Guo D., Li M., Zhang Y., Yang P., Eckenrode S., Hopkins D., Zheng W., Purohit S., Podolsky R.H., Muir A., Wang J., Dong Z., Brusko T., Atkinson M., Pozzilli P., Zeidler A., Raffel L.J., Jacob C.O. Wang C.-Y.Nat. Genet. 36:837-841(2003). [2]"A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus."Bohren K.M., Nadkarni V., Song J.H., Gabbay K.H., Owerbach D.J. Biol. Chem. 279:27233-27238(2003). [3]"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress."Guo D., Han J., Adam B.-L., Colburn N.H., Wang M.-H., Dong Z., Eizirik D.L., She J.-X., Wang C.-Y.Biochem. Biophys. Res. Commun. 337:1308-1318(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	dJ281H8.4;IDDM5;insulin-dependent diabetes mellitus 5;small ubiquitin-like modifier 4 protein;Small ubiquitin-like protein 4;small ubiquitin-related modifier 4;SMT3 suppressor of mif two 3 homolog 2;SMT3 suppressor of mif two 3 homolog 4;SMT3H4;SUMO-4.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	SUMO4
Gene Fullname	small ubiquitin like modifier 4
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
Nucleotide accession_num	NM_001002255
Protein accession_num	NP_001002255
Protein name	Small ubiquitin-related modifier 4
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Small ubiquitin-related modifier 4 protein (1-95AA)

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Menge: 100 ul

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