CAMK4 Antibody

ArtNr	OACA07826-100UL
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Culture Cytokines Cell Status Apoptosis Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies By Organ Bladder Cancer Colorectal Cancer Testicular & Prostate Cancer Immunostaining Glial Cell Markers Stem Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007). [2]"Crystal structure of human CAMK4 in complex with 4-amino(sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)."Muniz J.R.C., Rellos P., Gileadi O., Fedorov O., Filippakopoulos P., Salah E., Pike A., Phillips C., Niesen F., Shrestha L., Burgess-Brown N., Bullock A., Berridge G., Vondelft F., Edwards A.M., Bountra C., Arrowsmith C.H., Weigelt J., Knapp S.Submitted (NOV-2008). [3]"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	brain Ca(2+)-calmodulin-dependent protein kinase type IV;brain Ca++-calmodulin-dependent protein kinase type IV;calcium/calmodulin-dependent protein kinase type IV;calcium/calmodulin-dependent protein kinase type IV catalytic chain;CAM kinase- GR;CAM kinase IV;CaM kinase-GR;caMK;CaMK IV;CaMK-GR;CaMKIV.
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	CAMK4
Gene Fullname	calcium/calmodulin dependent protein kinase IV
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Nucleotide accession_num	NM_001323374
Protein accession_num	NP_001310303
Protein name	Calcium/calmodulin-dependent protein kinase type IV
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Calcium/calmodulin-dependent protein kinase type IV protein (304-473AA)

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Menge: 100 ul

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Lieferung vsl. bis 27.11.2025

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