TMEM64 Antibody

ArtNr	OACA09490-100UG
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Cell Biology Cell Culture Cytokines Adenocarcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Immunostaining Lymphatic System Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	transmembrane protein 64.
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	TMEM64
Gene Fullname	transmembrane protein 64
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
Nucleotide accession_num	NM_001008495
Protein accession_num	NP_001008495
Protein name	Transmembrane protein 64
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Transmembrane protein 64 protein (40-118AA)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OACA09490-100UG-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 29.01.2026

Express-Lieferung: 10 Tage sparen

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