DKK1 Antibody

ArtNr	OACD00245-1ML
Hersteller	AVIVA Systems Biology
Menge	1 ml
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Antibodies By Cell Type Carcinoma Obesity Immunohistochemistry Western Blot Immunocytochemistry Lipoprotein Receptors & Associated Proteins Primary Antibodies
Format	Liquid
Applikationen	WB, IHC
Clon	17#
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG2b Kappa
Alias	dickkopf 1 homolog;dickkopf-1 like;dickkopf-like protein 1;dickkopf-related protein 1;DKK-1;SK.
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Application Additional Information	Western blotting: 0.5-5 ug/mL Immunocytochemistry in formalin fixed cells: 5-30 ug/mL Immunohistochemistry in formalin fixed frozen section: 5-30 ug/mL Immunohistochemistry in paraffin section: 5-30 ug/mL Enzyme-linked Immunosorbent Assay: 0.05-2 ug/mL Optimal working dilutions must be determined by end user.
Gene symbol	DKK1
Gene Fullname	dickkopf WNT signaling pathway inhibitor 1
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Nucleotide accession_num	NM_012242.2
Protein accession_num	NP_036374.1
Protein name	Dickkopf-related protein 1
Clonality	Monoclonal
Purification	Protein A/G Purified
Immunogen	DKK1 Recombinant Protein (OPCD02745)
Concentration	1 mg/ml

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OACD00245-1ML-datasheet.pdf

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Menge: 1 ml

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Lieferung vsl. bis 29.01.2026

Express-Lieferung: 10 Tage sparen

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