HSPA9 (75kD glucose-regulated protein)

Antibodies / Antibodies-Heat Shock Proteins

4°C/-20°C

Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.

A synthetic peptide corresponding to a sequence at the C-terminal of human HSPA9, identical to the related rat and mouse sequences.

HSPA9(heat shock 70kDa protein 9 (mortalin)), also known as GRP75, mot-2, mthsp75, PBP74,
HSPA9B, MORTALIN or MORTALIN, PERINUCLEAR, is a highly conserved member of the HSP70
family of proteins. It functions as a chaperone in the mitochondria, cytoplasm, and centrosome.
The HSPA9 gene is mapped to chromosome 5q31.2 based on an alignment of the HSPA9 sequence
with the genomic sequence. Knockdown of HSPA9 in erythroid cultures was associated with an
increased number of cells in the G0/G1 phase of the cell cycle and accelerated apoptosis. Knockdown
of Hspa9 in mouse bone marrow cells, followed by transplantation into wildtype recipients, also resulted
in loss of erythroid cell number. Haploinsufficiency for HSPA9 may contribute to abnormal
hematopoiesis in myelodysplastic syndromes with deletions spanning chromosome 5q31.2. This protein
plays a role in the control of cell proliferation. It may also act as a chaperone.

UniProt Number:
P38646

Gene ID:
HSPA9

Applications:
Suitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.