IRF4 (Multiple Myeloma Oncogene 1, NF-EM5, Lymphocyte-specific Interferon Regulatory Factor, LSIRF, Interferon Regulatory Factor 4, IRF-4, IRF4, MUM1, FLJ14868, FLJ22283, HSPC211, MGC131891, MGC163315, MUM-1)

Antibodies / Antibodies-Transcription Factors

-20°C

Supplied as a liquid in PBS, 0.02% sodium azide.

Synthetic peptide corresponding to 16aa from near the C-terminus of human IRF4.

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.

Applications:
Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunocytochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1ug/ml
Immunocytochemistry: 10ug/ml
Immunofluorescence: 20ug/ml
Optimal dilutions to be determined by the researcher.

Positive Control:
Jurkat Cell Lysate

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.