TLR2 (CD282, Toll like receptor 2, Toll like receptor 2 precursor, Toll/interleukin 1 receptor like 4, Toll/interleukin receptor like protein 4, TIRAP, MAL, TIR domain containing adaptor protein)

Antibodies / Antibodies-Toll Like Receptors (TLR)

-20°C

Supplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.

Synthetic peptide corresponding human TLR2 at N-terminus.

TLR2 (Toll Like Receptor 2).Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB (4-6). TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins, respectively (reviewed in 7).

Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:5000-1:25, 000
Western Blot: 1:500-1:3000, expect a ~100kD band in the appropriate cell lysate or extract.
Immunohistochemistry: 2ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.