DR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (PE)

Antibodies / Antibodies-Apoptosis

4°C Do Not Freeze

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Residues aa280-296 (EHLLEPAEAERSQRRRL) of human DR5.

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. A distinct receptor for TRAIL, TRAIL-R2 is widely expressed and the gene encoding TRAIL-R2 is located on human chromosome 8p22-21. TRAIL-R2 engages a caspase-dependent apoptotic pathway but, in contrast to TRAIL-R1, TRAIL-R2 mediates apoptosis via the intracellular adaptor molecule FADD/MORT1.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.