Ddr1 (Epithelial discoidin Domain-Containing Receptor 1, Epithelial discoidin Domain Receptor 1, CD167 antigen-like Family Member A, Cell Adhesion Kinase, Discoidin Receptor Tyrosine Kinase, Protein-Tyrosine Kinase MPK-6, Tyrosine Kinase DDR, Ty

Antibodies / Antibodies-Receptors

-20°C

Supplied as a liquid in PBS, 0.09% sodium azide.

KLH conjugated synthetic peptide corresponding to aa396-430 at the Central region of human Mouse Ddr1. Species sequence homology: rat

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.