Anti-Tau [pS422] (clone 2H9)

Room temperature

12 months at -20°C
1 month at 4°C

Unconjugated

The measured concentration of the purified Anti-Tau [pS422] was 1 mg/ml as determined using a total protein concentration assay.

Research Use Only Product (RUO) / Not for Diagnosis or Therapeutic Use.

Lam S, Petit F, Hérard AS, Boluda S, Eddarkaoui S, Guillermier M, The Brainbank Neuro-CEB Neuropathology Network, Buée L, Duyckaerts C, Haïk S, Picq JL, Dhenain M (2021) Amyloid and tau pathologies, cognitive impairments and cerebral atrophy after Alzheimer brain extracts inoculation in a primate. Acta Neuropathol Commun. in press
Lam S, Boluda S, Hérard AS, Petit F, Eddarkaoui S, Cambon K, The Brainbank Neuro-CEB Neuropathology Network, Picq JL, Buee L, Duyckaerts C, Haïk S and Dhenain M (2021) Alzheimer’s brain inoculation in Aß-plaque bearing mice: synaptic loss is linked to tau seeding and low microglial activity. BioRxiv preprint doi: https://doi.org/10.1101/2021.04.06.438654;
Tautou M, Eddarkaoui S, Descamps F, Larchanché P-E, El Bakali J, Goveas LM, Dumoulin M, Lamarre C, Blum D, Buée L, Melnyk P and Sergeant N (2021) A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory ina Mouse Model of Neurofibrillary Degeneration. Front. Pharmacol. Vol 12:679335. doi: 10.3389/fphar.2021.679335
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D and Buee L (2012) Targeting phospho-Ser422 by active Tau Immunotherapy in the THY-Tau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res. 9(4):397-405.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P (2019). New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease. Neurobiol Dis. Vol. 129:217-233.
Sergeant N, Bretteville A, Hamdane M, Caillet-Boudin ML, Grognet P, Bombois S, Blum D, Delacourte A, Pasquier F, Vanmechelen E , Schraen-Maschke S, and Buee L (2008) Biochemistry of Tau in Alzheimer’s disease and related neurological disorders. Expert review of proteomics 5:207–224.