Vergleich

Goat Anti-SIRT1 Antibody

ArtNr ABC-AF1993a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products SIRT1, SIR2L1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, 75SirT1, SirtT1 75 kDa fragment, 3.5.1.-
Lieferbar
Primary Accession
Q96EB6
Antigen Type
Synthetic Peptide
Application
WB, E
Bio Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Bio References
SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Fan W, et al. Mol Cell, 2010 Jul 30. PMID 20670893.
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. Satoh A, et al. J Neurosci, 2010 Jul 28. PMID 20668205.
SIRT1 variants are associated with aging in a healthy Han Chinese population. Zhang WG, et al. Clin Chim Acta, 2010 Nov 11. PMID 20633545.
Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Calvanese V, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20631301.
MicroRNA-34a regulation of endothelial senescence. Ito T, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20627091.
Clonality
Polyclonal
Gene ID
23411
Gene Name
SIRT1 (HGNC:14929)
Subtitle
Peptide-affinity purified goat antibody
Reactivity
M
Legend image 1
AF1993a (1 µg/ml) staining of Mouse fetal Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1
WB
Other Accession
NP_036370; 23411; 93759 (mouse); 309757 (rat);
Predicted
H, Rat, Dog
Concentration (mg/ml)
100ug/200ul

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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