FMR1 / FMRP Antibody (clone 1D10)

Human FMR1 / FMRP

Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

FMR1 {ECO:0000303|PubMed:8504300, ECO:0000312|HGNC:HGNC:3775}

H, M, Rat, Pr, D

Protein A/G purified

IHC-P (10 µg/ml), WB (1:500 - 1:2000),