MME/CD10 Antibody (ascites)

Primary Antibodies; Cancer; Immunology; Signal Transduction

This gene encodes a common acute lymphocytic leukemiaantigen that is an important cell surface marker in the diagnosisof human acute lymphocytic leukemia (ALL). This protein is presenton leukemic cells of pre-B phenotype, which represent 85% of casesof ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoproteinthat is particularly abundant in kidney, where it is present on thebrush border of proximal tubules and on glomerular epithelium. Theprotein is a neutral endopeptidase that cleaves peptides at theamino side of hydrophobic residues and inactivates several peptidehormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 1-kD type IItransmembrane glycoprotein, exists in a single copy of greater than45 kb. The 5' untranslated region of this gene is alternativelyspliced, resulting in four separate mRNA transcripts. The codingregion is not affected by alternative splicing. [provided byRefSeq].

MME {ECO:0000303|PubMed:27588448, ECO:0000312|HGNC:HGNC:7154}

H

HUMAN

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Synthetic Peptide