Bio Background |
The protein encoded by this gene belongs to the family ofP-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane proteinresponsible for establishing and maintaining the electrochemicalgradients of Na and K ions across the plasma membrane. Thesegradients are essential for osmoregulation, for sodium-coupledtransport of a variety of organic and inorganic molecules, and forelectrical excitability of nerve and muscle. This enzyme iscomposed of two subunits, a large catalytic subunit (alpha) and asmaller glycoprotein subunit (beta). The catalytic subunit ofNa+/K+ -ATPase is encoded by multiple genes. This gene encodes analpha 1 subunit. Multiple transcript variants encoding differentisoforms have been found for this gene. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Holthouser, K.A., et al. Am. J. Physiol. Renal Physiol. 299 (1), F77-F90 (2010) :Comellas, A.P., et al. J. Cell. Sci. 123 (PT 8), 1343-1351 (2010) :Floyd, R.V., et al. Reprod Sci 17(4):366-376(2010)Xu, Z.W., et al. Zhonghua Yi Xue Za Zhi 90(12):813-817(2010) |