Bio Background |
The protein encoded by this gene plays a crucial role inB-cell development. Mutations in this gene cause X-linkedagammaglobulinemia type 1, which is an immunodeficiencycharacterized by the failure to produce mature B lymphocytes, andassociated with a failure of Ig heavy chain rearrangement. |
Bio References |
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ng, Y.Y., et al. Leukemia 24(9):1617-1630(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Marcotte, D.J., et al. Protein Sci. 19(3):429-439(2010)Liu, Z., et al. J. Immunol. 184(1):244-254(2010) |