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PARK8 (LRRK2) Antibody

PARK8 (LRRK2) Antibody

ArtNr	ABC-AM7099b-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Neuroscience Neuroinflammation Neural Mitochondrial Function Molecular Targets for Neuroscience Antibodies Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	133AT720
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG1
Citations	Olfactory heterogeneity in LRRK2 related Parkinsonism. Silveira-Moriyama L, et al. Mov Disord, 2010 Sep 3. PMID 20818658. LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease. Saunders-Pullman R, et al. Mov Disord, 2010 Sep 3. PMID 20818610. Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease. Yescas P, et al. Neurosci Lett, 2010 Aug 18. PMID 20727385. Absence of Commonly Reported Leucine-Rich Repeat Kinase 2 Mutations in Eastern Indian Parkinson's Disease Patients. Sanyal J, et al. Genet Test Mol Biomarkers, 2010 Aug 19. PMID 20722494. Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain). Ruiz-Martínez J, et al. Mov Disord, 2010 Aug 18. PMID 20721916.
NCBI	NP_940980.3
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Leucine-rich repeat serine/threonine-protein kinase 2,Dardarin,LRRK2,PARK8
Similar products	LRRK2, PARK8, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin
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Manufacturer - Category	Primary Antibodies; Neuroscience; Autophagy; Lysosome; Mitochondrion; Mitochondrion outer membrane
Manufacturer - Targets	This PARK8 (LRRK2) antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.
Bio Background	This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD4 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Clonality	Monoclonal
Gene Name	LRRK2
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H, M
Calculated Molecular Weight	286103
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:1000

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Menge: 80 ul

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