STAT3 Antibody

ArtNr	ABC-AM8415b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	1200CT146.104.153
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Akira S.,et al.Cell 77:63-71(1994). Della Pietra L.,et al.Gene 213:119-124(1998). Ota T.,et al.Nat. Genet. 36:40-45(2004). Della Pietra L.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases. Zhang X.,et al.Science 267:1990-1994(1995).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Signal transducer and activator of transcription 3,Acute-phase response factor,STAT3,APRF
Similar products	STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor
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Manufacturer - Category	Crown Antibodies; Primary Antibodies; Cancer; Cardiovascular; Developmental Biology; Microbiology; Signal Transduction; Viral process; Host-virus interaction; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; JAK-STAT signaling; Jak-STAT signaling KEGG
Manufacturer - Targets	This STAT3 antibody is generated from a mouse immunized with a recombinant protein from human.
Bio Background	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Clonality	Monoclonal
Gene Name	STAT3 {ECO:0000303\|PubMed:9630560, ECO:0000312\|HGNC:HGNC:11364}
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Predicted Reactivity	M, Pig, Rat
Calculated Molecular Weight	88068
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	IHC: 1:5000 WB: 1:1000
Antigen Type	Recombinant Protein

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