SQSTM1 Antibody

ArtNr	ABC-AM8447b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Cell Biology Cell Status Adenocarcinoma Western Blot Autophagy Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	1336CT763.152.125
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Devergne O.,et al.J. Virol. 70:1143-1153(1996). Joung I.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:5991-5995(1996). Ota T.,et al.Nat. Genet. 36:40-45(2004). Schmutz J.,et al.Nature 431:268-274(2004). Vadlamudi R.K.,et al.FEBS Lett. 435:138-142(1998).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Sequestosome-1,EBI3-associated protein of 60 kDa,EBIAP,p60,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,Ubiquitin-binding protein p62,SQSTM1,ORCA,OSIL
Similar products	SQSTM1, p60, ORCA, OSIL, Sequestosome-1, EBI3-associated protein of 60 kDa, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBIAP
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Manufacturer - Category	Primary Antibodies; Cardiovascular; Metabolism; Signal Transduction; Immunity; Autophagy; Lysosome; SARS-Human interaction partners
Manufacturer - Targets	This SQSTM1 antibody is generated from mice immunized with a recombinant protein.
Bio Background	Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Clonality	Monoclonal
Gene Name	SQSTM1 {ECO:0000303\|PubMed:16286508, ECO:0000312\|HGNC:HGNC:11280}
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	47687
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:2000

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Menge: 400 ul

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