MB21D1 Antibody

ArtNr	ABC-AM8562b-ev
Hersteller	Abcepta
Menge	50 ul
Kategorie	Antibodies Cell Biology Cell Status Necrosis Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	1697CT136.65.30
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Sun L.,et al.Science 339:786-791(2013). Ota T.,et al.Nat. Genet. 36:40-45(2004). Mungall A.J.,et al.Nature 425:805-811(2003). Choudhary C.,et al.Science 325:834-840(2009). Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cyclic GMP-AMP synthase,cGAMP synthase,cGAS,h-cGAS,2.7.7.86,Mab-21 domain-containing protein 1,MB21D1,C6orf150
Similar products	C6orf150, MB21D1, Cyclic GMP-AMP synthase, cGAS, cGAMP synthase, h-cGAS, Mab-21 domain-containing protein 1, 2.7.7.86
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Manufacturer - Category	Crown Antibodies; Primary Antibodies; Cell Biology; Antiviral defense; Immunity; Inflammasome; Innate immunity; Immune system process
Manufacturer - Targets	This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-185 amino acids from human MB21D1.
Bio Background	Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2', 5' phosphodiester linkage at the GpA step and the formation of a 3', 5' phosphodiester linkage at the ApG step, producing c[G(2', 5')pA(3', 5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
Clonality	Monoclonal
Gene Name	CGAS {ECO:0000303\|PubMed:23258413, ECO:0000312\|HGNC:HGNC:21367}
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	58814
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:4000
Antigen Type	Recombinant Protein

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Menge: 50 ul

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Lieferung vsl. bis 01.01.2026

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